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Related Concept Videos

Spinal Cord: Information Processing01:10

Spinal Cord: Information Processing

The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...
Spinal Cord01:26

Spinal Cord

The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.
The Spinal Cord01:54

The Spinal Cord

The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.
Motor Unit Stimulation01:20

Motor Unit Stimulation

When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...

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Related Experiment Video

Updated: Jun 18, 2026

The Ex vivo Preparation of Spinal Cord Slice for the Whole-Cell Patch-Clamp Recording in Motor Neurons During Spinal Cord Stimulation
06:55

The Ex vivo Preparation of Spinal Cord Slice for the Whole-Cell Patch-Clamp Recording in Motor Neurons During Spinal Cord Stimulation

Published on: September 8, 2023

[Spinal cord stimulation].

Keita Fukazawa1, Toyoshi Hosokawa

  • 1Department of Pain Treatment and Palliative Medicine, Kyoto Prefectural University of Medicine, Kyoto 602-8566.

Masui. the Japanese Journal of Anesthesiology
|November 26, 2009
PubMed
Summary
This summary is machine-generated.

Spinal cord stimulation (SCS) offers relief for intractable neuropathic pain by modulating nerve signals. A less invasive puncture trial method enhances patient acceptance for this established pain management technique.

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Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
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Related Experiment Videos

Last Updated: Jun 18, 2026

The Ex vivo Preparation of Spinal Cord Slice for the Whole-Cell Patch-Clamp Recording in Motor Neurons During Spinal Cord Stimulation
06:55

The Ex vivo Preparation of Spinal Cord Slice for the Whole-Cell Patch-Clamp Recording in Motor Neurons During Spinal Cord Stimulation

Published on: September 8, 2023

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
04:42

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

Area of Science:

  • Neuromodulation
  • Pain Management
  • Neuroscience

Context:

  • Spinal cord stimulation (SCS) is a recognized therapy for difficult neuropathic pain.
  • It involves implantable devices stimulating dorsal column fibers to create paresthesia over painful areas.
  • The mechanism is rooted in the Gate Control Theory and involves neurochemical changes in the dorsal horns.

Purpose:

  • To explain the mechanism of action of Spinal Cord Stimulation (SCS).
  • To outline the clinical indications for SCS.
  • To introduce a less invasive puncture trial method for SCS.

Summary:

  • SCS utilizes an implantable pulse generator and electrodes in the dorsal epidural space to stimulate nerve fibers, based on the Gate Control Theory.
  • It modulates pain by releasing neurotransmitters like serotonin and GABA, and activating GABAB receptors, reducing excitatory amino acid release.
  • Clinical applications include peripheral vascular diseases, refractory angina, failed back surgery syndrome, complex regional pain syndromes, spinal cord stenosis, and neuropathic pain.

Impact:

  • SCS provides an effective treatment option for various chronic pain conditions.
  • Understanding its neurochemical effects deepens our knowledge of pain modulation.
  • The development of less invasive techniques, like the puncture trial, can improve patient access and adherence to SCS therapy.