[Flumazenil restores amnesic trace of memory in mice with depression-like state]

Experiments on C57BL/6J mice of submissive stereotype and behavioral despair response and ASC/Icg mice with high predisposition to catalepsy, which served as depression-like state models, were used to study the influence of benzodiazepine receptor antagonist flumazenil on the restoration of a passive avoidance reaction learned under conditions of the amnesic effect of animal detention in a dark compartment. It is established, that flumazenil (10 mg/kg) reactivated retrieval of the amnesic memory trace in mice of submissive stereotype with the behavioral despair response, while being ineffective in ASC mice.