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Refractive errors and strabismus in children with tuberous sclerosis: a controlled study.

Arsen Akinci¹, Ozgur Oner, Alev Guven

¹Department of Pediatric Ophthalmology, Diskapi Children's Hospital, Ankara, Turkey.

Journal of Pediatric Ophthalmology and Strabismus

|November 26, 2009

Summary

Children with tuberous sclerosis (TS) show a higher prevalence of hypermetropia and amblyopia. Early screening for these vision issues is crucial for managing this genetic disorder.

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Area of Science:

Ophthalmology
Genetics
Pediatrics

Background:

Tuberous sclerosis (TS) is a genetic disorder that affects multiple organs.
Ocular manifestations in TS are not fully understood.
Refractive errors and strabismus are common in childhood.

Purpose of the Study:

To determine the prevalence of refractive errors and strabismus in children with TS.
To compare ocular findings in children with TS to a control group.

Main Methods:

A cohort of 23 children with TS and 151 controls underwent comprehensive eye examinations.
Examinations included cycloplegic autorefraction, slit-lamp biomicroscopy, and dilated fundus evaluation.
Ocular alignment was assessed using standard clinical tests.

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Main Results:

Children with TS had a significantly higher prevalence of hypermetropia (farsightedness) compared to controls.
Amblyopia (lazy eye) was also more prevalent in the TS group.
Statistical significance was observed for both conditions (P = .035 for TS, P = .002 for controls).

Conclusions:

Hypermetropia appears to be a common feature associated with tuberous sclerosis.
Early detection and management of hypermetropia are recommended in children with TS.
This screening can help prevent amblyopia and preserve visual function.