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Refractive errors and strabismus in children with tuberous sclerosis: a controlled study
Arsen Akinci1, Ozgur Oner, Alev Guven
1Department of Pediatric Ophthalmology, Diskapi Children's Hospital, Ankara, Turkey.
Insights
Children with tuberous sclerosis (TS) show a higher prevalence of hypermetropia and amblyopia. Early screening for these vision issues is crucial for managing this genetic disorder.
Area of Science:
- Ophthalmology
- Genetics
- Pediatrics
Background:
- Tuberous sclerosis (TS) is a genetic disorder that affects multiple organs.
- Ocular manifestations in TS are not fully understood.
- Refractive errors and strabismus are common in childhood.
Purpose of the Study:
- To determine the prevalence of refractive errors and strabismus in children with TS.
- To compare ocular findings in children with TS to a control group.
Main Methods:
- A cohort of 23 children with TS and 151 controls underwent comprehensive eye examinations.
- Examinations included cycloplegic autorefraction, slit-lamp biomicroscopy, and dilated fundus evaluation.
- Ocular alignment was assessed using standard clinical tests.
Main Results:
- Children with TS had a significantly higher prevalence of hypermetropia (farsightedness) compared to controls.
- Amblyopia (lazy eye) was also more prevalent in the TS group.
- Statistical significance was observed for both conditions (P = .035 for TS, P = .002 for controls).
Conclusions:
- Hypermetropia appears to be a common feature associated with tuberous sclerosis.
- Early detection and management of hypermetropia are recommended in children with TS.
- This screening can help prevent amblyopia and preserve visual function.
Purpose:
To evaluate the prevalence of refractive errors and strabismus in children with tuberous sclerosis and in control subjects.
Methods:
Twenty-three children with tuberous sclerosis and 151 control subjects were evaluated. All children underwent cycloplegic autorefraction or retinoscopy, slit-lamp biomicroscopy, and dilated fundus examination. Ocular alignment was assessed by the Hirschberg, Krimsky, or prism cover test.
Results:
The total prevalence of hypermetropia and amblyopia was significantly higher in patients with tuberous sclerosis (P = .035) than in the control subjects (P = .002).
Conclusion:
A high prevalence of hypermetropia seems to be an additional feature of tuberous sclerosis. Early screening for this amblyogenic factor is indicated in patients with tuberous sclerosis.
