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Chronic suppurative otitis media in cleft palate: microorganism etiology and susceptibilities

Paulo Henrique Weckwerth1, Carlos Alberto de Magalhães Lopes, Marco Antonio Húngaro Duarte

  • 1University of Sagrado Coração, Bauru, Brazil. phweck@terra.com.br

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
|November 26, 2009
PubMed
Abstract

Insights

Suppurative chronic otitis media (SCOM) in cleft palate patients showed 100% bacterial growth, with Pseudomonas and enterobacteriaceae being most common. Imipenem and ciprofloxacin demonstrated broad effectiveness against these SCOM pathogens.

Area of Science:

  • Microbiology
  • Otolaryngology
  • Genetics

Background:

  • Suppurative chronic otitis media (SCOM) is a common complication in patients with cleft lip and palate (CLP) and isolated cleft palate (CP).
  • Understanding the specific microbial agents and their antibiotic susceptibility is crucial for effective treatment in this vulnerable population.

Purpose of the Study:

  • To identify the causative microorganisms in SCOM among patients with CLP and CP.
  • To evaluate the in vitro antibiotic susceptibility of these isolated bacteria.

Main Methods:

  • Bacteriological analysis of SCOM effusion samples from 40 CLP/CP patients using cultures.
  • In vitro antibiotic susceptibility testing of isolated bacterial strains via drug diffusion and dilution methods.

Main Results:

  • 100% of cases yielded positive bacterial cultures, with 57 strains identified.
  • Dominant bacteria included Pseudomonas aeruginosa (35%), Staphylococcus aureus (15.5%), Enterococcus faecalis (14%), and Proteus mirabilis (12%).
  • Pseudomonas aeruginosa showed high sensitivity to ciprofloxacin; enterobacteriaceae to gentamicin; S. aureus to imipenem; E. faecalis to sulfamethoxazole/trimethoprim.

Conclusions:

  • SCOM in CLP/CP patients consistently involves bacterial infections, frequently by Pseudomonas and enterobacteriaceae.
  • Imipenem was effective against all four major isolated species, while ciprofloxacin was effective against 75%.

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