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Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Related Experiment Video

Updated: Jun 18, 2026

Direct Reprogramming of Mouse Fibroblasts into Melanocytes
09:38

Direct Reprogramming of Mouse Fibroblasts into Melanocytes

Published on: August 27, 2021

Vitiligo therapy.

Torello Lotti1, Samantha Berti, Silvia Moretti

  • 1University of Florence, Department of Dermatological Sciences, Via della Pergola, 60, 50121 Florence, Italy.

Expert Opinion on Pharmacotherapy
|November 26, 2009
PubMed
Summary
This summary is machine-generated.

Vitiligo treatment options include phototherapy like narrow-band ultraviolet B (NB-UVB) and excimer laser for specific types. Combination therapies and surgical options are also available for stable vitiligo.

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Area of Science:

  • Dermatology
  • Phototherapy
  • Medical Treatments

Background:

  • Vitiligo is a chronic skin condition characterized by depigmentation.
  • Various treatment modalities exist, ranging from topical therapies to advanced light-based treatments.

Purpose of the Study:

  • To review current and experimental therapies for vitiligo.
  • To outline indications for different phototherapy and medical treatments.
  • To discuss the role of combination therapies and surgical interventions.

Main Methods:

  • Review of existing literature on vitiligo treatments.
  • Categorization of therapies based on mechanism and indication.
  • Analysis of treatment outcomes for different vitiligo subtypes.

Main Results:

  • Narrow-band ultraviolet B microphototherapy (NB-UVB) is recommended for generalized vitiligo.
  • Narrow-band ultraviolet B excimer laser and monochromatic excimer light are indicated for segmental and bilateral symmetrical vitiligo with limited skin involvement (<20%).
  • Topical treatments include corticosteroids, antioxidants, calcineurin inhibitors (tacrolimus, pimecrolimus), prostaglandin E, and vitamin D derivatives.

Conclusions:

  • Combination treatments can yield excellent therapeutic results in vitiligo management.
  • Surgical interventions are reserved for adolescent or adult patients with stable vitiligo.
  • Current therapeutic strategies offer diverse options for vitiligo patients based on disease extent and stability.