Related Experiment Videos
Exploration of the DPP-4 inhibitors with a focus on saxagliptin
Jay H Shubrook1, Randall A Colucci, Frank L Schwartz
1Ohio University College of Osteopathic Medicine, Family Medicine, Grosvenor Hall 349, Athens, OH 45701, USA. shubrook@ohio.edu
Background:
Type 2 diabetes (T2DM) has become a worldwide epidemic. Despite a vast array of new compounds to treat T2DM, recommended treatment goals are consistently not achieved in this country thus suggesting a need to increase treatment options.
Objective:
To review the role of DPP-4 inhibitors in treatment of T2DM with an emphasis on saxagliptin.
Methods:
The authors discuss the role of this new class of medications in treatment of T2DM, review the current available studies and the unique characteristics of saxagliptin.
Results And Conclusions:
Saxagliptin, a DPP-4 inhibitor, is one of an important new class of compounds, which seems to be particularly safe and effective especially in early treatment of T2DM.
Related Concept Videos
Dipeptidyl Peptidase 4 Inhibitors
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...
Oral Hypoglycemic Agents: Biguanides and Glitazones
Oral Hypoglycemic Agents: Glinides
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are typically...
Oral Hypoglycemic Agents: Sulfonylureas