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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
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Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
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Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Related Experiment Video

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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Cutaneous lymphangioma circumscriptum: frog spawn on the skin.

Gopal A Patel1, Robert A Schwartz

  • 1Dermatology and Pathology New Jersey Medical School, Newark, NJ 07103-2714, USA.

International Journal of Dermatology
|November 26, 2009
PubMed
Summary

Lymphangiomas are congenital lymphatic malformations affecting skin and intestines. Cutaneous lymphangioma circumscriptum (CLC) requires differentiation from skin carcinoma due to recurrence potential.

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Area of Science:

  • Vascular Malformations
  • Pediatric Oncology
  • Dermatopathology

Background:

  • Lymphangiomas are congenital lymphatic system malformations.
  • They represent 4% of vascular tumors and 25% of benign pediatric vascular growths.
  • Classified into cutaneous lymphangioma circumscriptum (CLC), cavernous lymphangiomas, and cystic hygromas.

Purpose of the Study:

  • To describe the characteristics of lymphangiomas.
  • To highlight the clinical presentation of CLC.
  • To emphasize the importance of distinguishing CLC from carcinoma telangiectoides.

Main Methods:

  • Review of existing literature on lymphangiomas.
  • Analysis of clinical features and classifications.
  • Differential diagnosis considerations for CLC.

Main Results:

  • Lymphangiomas involve skin, subcutaneous tissues, and intestines.
  • CLC is a specific type of lymphangioma.
  • Distinguishing CLC from carcinoma telangiectoides is crucial due to CLC's recurrence potential.

Conclusions:

  • Lymphangiomas are diverse congenital lymphatic malformations.
  • CLC requires careful diagnosis to differentiate it from malignant conditions.
  • Accurate diagnosis prevents misclassification and guides appropriate management.