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Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Lineage Commitment01:21

Lineage Commitment

Commitment is the  process whereby stem cells:
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
Histone Modification02:32

Histone Modification

The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...

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Related Experiment Video

Updated: Jun 18, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Epigenetic modulation in hematologic malignancies: challenges and progress.

Constantine S Mitsiades1, Kenneth C Anderson

  • 1Department of Medical Oncology, Harvard Medical School, Boston, MA, USA.

Journal of the National Comprehensive Cancer Network : JNCCN
|November 26, 2009
PubMed
Summary
This summary is machine-generated.

Cancer

Related Experiment Videos

Last Updated: Jun 18, 2026

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues
10:41

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Published on: April 5, 2018

Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Genetic alterations drive cancer development by activating oncogenes and inactivating tumor suppressor genes.
  • Tumor cell behavior is influenced not only by genetics but also by the microenvironment.
  • Epigenetic changes, alterations in gene expression not due to DNA sequence changes, are crucial in cancer.

Purpose of the Study:

  • To review the regulation of the epigenome in cancer cells.
  • To highlight DNA methylation and histone acetylation as key epigenetic mechanisms.
  • To discuss these epigenetic modifications as potential therapeutic targets in hematologic malignancies.

Main Methods:

  • This review synthesizes current literature on cancer epigenetics.
  • Focuses on mechanisms of DNA methylation and histone acetylation.
  • Examines their role in hematologic malignancies.

Main Results:

  • Epigenetic modifications significantly impact cancer cell phenotype and behavior.
  • DNA methylation and histone acetylation patterns are altered in neoplastic cells.
  • These epigenetic changes are heritable and influence gene expression.

Conclusions:

  • Epigenetic regulation plays a critical role in cancer biology beyond genetic alterations.
  • DNA methylation and histone acetylation are key epigenetic mechanisms in hematologic malignancies.
  • Targeting epigenetic modifications offers promising therapeutic strategies for blood cancers.