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Immunohistochemical detection of aquaporin expression in eutopic and ectopic endometria from women with endometriomas
Xiu-Xiu Jiang1, Riu-Jin Wu1, Kai-Hong Xu1
1Department of Gynecology and Obstetrics, Women's Hospital, Zhejiang University Medical College, Zhejiang Province, Hangzhou City, People's Republic of China.
Objective:
To investigate the expression of aquaporin (AQP) in eutopic and ectopic endometrial tissues from women with endometriomas.
Design:
Controlled laboratory research.
Setting:
Hospital-based unit for gynecology and obstetrics and research laboratories.
Patient(S):
Premenopausal women undergoing laparoscopy for endometriomas.
Intervention(S):
Endometrial biopsy samples obtained from 70 women with endometriomas.
Main Outcome Measure(S):
Semiquantitative analysis by immunohistochemistry.
Result(S):
Aquaporins 2, 5, and 8 were mainly located in luminal and glandular epithelia. The frequency of positive immunostaining for aquaporins 2, 5, and 8 decreased in ectopic compared with eutopic endometria. Aquaporins 2, 5, and 8 were found at a low frequency in the endometria in early proliferative phases but at a higher frequency in late proliferative and secretory phases. There were no significant differences in the menstrual cycle of the proliferative phase and secretory phase in the two groups.
Conclusion(S):
Aquaporins 2, 5, and 8 were expressed with greater frequency in eutopic endometrial cells than inectopic endometrial cells, suggesting that eutopic endometrial cells have stronger migration activity than ectopic endometrial cells in women with endometriosis.
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