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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

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Related Experiment Videos

[Skin aging: clinicopathological features and mechanisms].

C Beylot1

  • 1Professeur Emérite de l'Université Bordeaux 2 Victor-Segalen, CHU de Bordeaux, 101 boulevard Wilson, Bordeaux, France. claire.beylot@wanadoo.fr

Annales De Dermatologie Et De Venereologie
|November 26, 2009
PubMed
Summary

Skin aging varies greatly due to intrinsic and extrinsic factors. Dermatologists must understand these causes and mechanisms to provide effective cosmetic treatments for aging skin.

Related Experiment Videos

Area of Science:

  • Dermatology
  • Aging Biology

Context:

  • Skin aging exhibits significant individual variability.
  • Influenced by intrinsic factors (e.g., age, menopause) and extrinsic factors (e.g., UV exposure, smoking).

Purpose:

  • To describe the clinical and histological characteristics of skin aging.
  • To elucidate the complex mechanisms underlying skin aging.
  • To guide dermatologists in analyzing and treating skin aging, considering subcutaneous tissue changes.

Summary:

  • Details the diverse clinical and histological presentations of skin aging.
  • Explains the intricate biological mechanisms driving intrinsic and extrinsic skin aging.
  • Highlights the importance of addressing subcutaneous tissue aging in cosmetic dermatology.

Impact:

  • Enhances dermatologists' understanding of skin aging.
  • Provides a basis for tailored therapeutic strategies in cosmetic dermatology.
  • Improves patient consultation and management for skin aging concerns.