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Updated: Jun 18, 2026

Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
Published on: March 18, 2022
Radiographic grading and measurement of joint space width in osteoarthritis
Marie-Pierre Hellio Le Graverand1, Steve Mazzuca, Jeff Duryea
1Clinical Development and Medical Affairs, Inflammation, Specialty Care Business Unit, Pfizer Inc, 50 Pequot Avenue, New London, CT 06320, USA. helliomp@pfizer.com
Abstract:
The progression of osteoarthritis is traditionally measured using radiographic joint space width (JSW). Numerous knee radiograph protocols have been developed with various levels of complexity and performance as it relates to detecting JSW loss (ie, joint space narrowing). Sensitivity to joint space narrowing is improved when radioanatomic alignment of the medial tibial plateau is achieved. Semiautomated software has been developed to improve the accuracy of JSW measurement over manual methods. JSW measurements include minimum JSW, mean JSW or joint space area, and JSW at fixed locations.

