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Pharmacologic management of urinary incontinence, voiding dysfunction, and overactive bladder
1Division of Urogynecology and Pelvic Reconstructive Surgery, Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. emily.saks@uphs.upenn.edu
Obstetrics and Gynecology Clinics of North America
|November 26, 2009
Summary
Current pharmacotherapy for overactive bladder primarily uses antimuscarinic drugs with similar outcomes. Newer treatments targeting different mechanisms are under development for urinary incontinence and voiding dysfunction in women.
Area of Science:
- Urology
- Pharmacology
Background:
- Urinary incontinence and voiding dysfunction in women often involve neuromuscular transmission modulation.
- Pharmacotherapy is a primary treatment for overactive bladder.
Purpose of the Study:
- To review current pharmacotherapy for urinary incontinence and voiding dysfunction in women.
- To discuss the role of antimuscarinic medications and emerging drug targets.
Main Methods:
- Literature review of pharmacologic treatments for female urinary incontinence and voiding dysfunction.
- Analysis of drug mechanisms, efficacy, and tolerability.
Main Results:
- Antimuscarinic medications are the mainstay for overactive bladder, showing similar efficacy and tolerability.
- Pharmacotherapy has a limited role in stress incontinence and general voiding dysfunction.
- Novel drugs targeting diverse mechanisms are in development.
Conclusions:
- Current antimuscarinic treatments for overactive bladder are largely comparable.
- Future pharmacotherapy for urinary incontinence and voiding dysfunction will likely involve novel mechanisms of action.
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