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Published on: July 16, 2018
Plasma concentrations of apolipoproteins A-I, B and M in patients with abdominal aortic aneurysms
Josefin Ahnström1, Anders Gottsäter, Bengt Lindblad
1Wallenberg Laboratory, Department of Laboratory Medicine, Clinical Chemistry, Lund University, SE-205 02 Malmö, Sweden.
Objectives:
Apolipoproteins play important roles in the development of atherosclerosis but their involvement in the pathogenesis of abdominal aortic aneurysm (AAA) is poorly understood. The aim was to investigate whether apoA-I, apoB and apoM are independently associated with AAA.
Design And Methods:
Plasma apoA-I, apoB and apoM were measured in 343 patients with AAA and in 214 elderly apparently healthy control individuals from the background population.
Results:
AAA patients had lower apolipoprotein levels, as compared to healthy individuals: apoA-I, 1.62 vs. 2.08 g/L; apoB, 0.91 vs. 1.04 g/L; apoM, 0.72 vs. 0.91 mumol/L (p<0.0001 for all three). In multivariate analyses, apoA-I and apoB were associated with AAA, odds ratios (95% confidence intervals) being 0.53 (0.43-0.64) and 0.86 (0.75-0.998), respectively.
Conclusions:
ApoA-I, apoB and apoM levels were significantly lower in patients with AAA than in the control individuals, but only apoA-I and apoB were independently associated to AAA.
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