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Related Experiment Videos

Mathematical model for comparing proficiency testing results across analytical methods.

J P AuBuchon1

  • 1Department of Pathology, Dartmouth-Hitchcock Medical Center, Hanover, NH 03756.

Clinical Chemistry
|February 1, 1991
PubMed
Summary

A mathematical approach for alanine aminotransferase (ALT) proficiency testing failed due to method variability. This method, while useful for standardization, could not reliably compare results across different testing methods in PT programs.

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Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Analytical Chemistry

Background:

  • Proficiency testing (PT) programs are crucial for ensuring laboratory accuracy.
  • Establishing acceptable performance ranges in PT can be challenging for methods with few participants.
  • Alanine aminotransferase (ALT) testing is a common clinical chemistry assay.

Purpose of the Study:

  • To analyze a mathematical approach for setting acceptable performance in ALT PT challenges.
  • To evaluate the applicability of a previously successful standardization model to PT scenarios.
  • To determine if a ratio-based method can standardize results from diverse ALT testing methods in PT.

Main Methods:

  • Analysis of a mathematical model derived from a 1988 nationwide ALT standardization system.

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  • Calculation of result ratios between individual methods and a chosen "standard" method within PT challenges.
  • Assessment of the variability of these ratios over time for different methods.

    • Main Results:

    • The mathematical approach aimed to transform target values to accommodate less common methods.
    • High variability in method ratios over time prevented the general application of this approach in PT.
    • The method's success in a prior standardization system did not translate to PT result comparison.

    Conclusions:

    • The analyzed mathematical approach is not suitable for comparing results across different methods in ALT PT challenges.
    • Method-specific variability is a significant limitation for using ratio-based standardization in PT.
    • While useful for initial standardization, this approach does not ensure comparability in ongoing PT programs.