H-InvDB in 2009: extended database and data mining resources for human genes and transcripts

Area of Science:

• Genomics
• Bioinformatics
• Molecular Biology

Background:

• The H-Invitational Database (H-InvDB) is a crucial resource for human gene and transcript annotation.
• Previous versions provided foundational data for researchers in human genetics.

Purpose of the Study:

• To announce the release of an updated H-InvDB with extended database and data mining functionalities.
• To enhance accessibility and analytical capabilities for human genomic data.

Main Methods:

• The latest release (6.2) annotates 219,765 human transcripts across 43,159 gene clusters using full-length cDNA and mRNA data.
• Integration of new features including microarray probe mapping, novel gene models, ncRNA relations, and Glycogene database information.
• Development of advanced data mining tools: Navigation search and H-InvDB Enrichment Analysis Tool (HEAT).

Main Results:

• H-InvDB release 6.2 provides comprehensive annotation for a large set of human transcripts and gene clusters.
• New features facilitate deeper analysis, including identification of specific gene set characteristics via HEAT.
• Web service APIs (SOAP and REST) are now available for programmatic data access.

Conclusions:

• The updated H-InvDB significantly enhances the utility of human genomic data for research.
• Expanded data mining and accessibility features empower researchers with advanced analytical tools.