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Related Experiment Video

Updated: Jun 18, 2026

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication

Published on: December 11, 2013

Intermittent pneumatic compression in stable claudicants: effect on hemostasis and endothelial function.

E Sutkowska¹, M Wozniewski, A Gamian

¹Department of Physical Therapy and Rehabilitation, University School of Physical Education, Wroclaw, Poland.

International Angiology : a Journal of the International Union of Angiology

|November 26, 2009

Summary

Intermittent pneumatic compression (IPC) is safe for peripheral arterial disease (PAD) patients, reducing platelet activation and improving endothelial health. This therapy significantly increases pain-free walking distance in PAD patients.

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Area of Science:

Vascular Medicine
Cardiovascular Research
Biomedical Engineering

Background:

Intermittent pneumatic compression (IPC) enhances fibrinolysis but raises concerns about endothelial injury and coagulation in peripheral arterial disease (PAD).
The safety and efficacy of IPC in PAD patients remain uncertain due to potential pro-coagulant effects.

Purpose of the Study:

To evaluate the association of IPC with coagulation activation and endothelial cell damage in PAD patients.
To assess changes in platelet factor 4 (PF4), thrombin-antithrombin complex (TAT), nitrate/nitrite levels, and von Willebrand factor (VWF) concentration.

Main Methods:

A study involving 25 claudicants and 11 healthy volunteers.
Analysis of PF4, TAT, total nitrate, nitrite, and VWF before and after IPC sessions, and 3 weeks post-therapy.
Comparison of outcomes between PAD patients and a healthy control group.

Main Results:

PAD patients initially showed higher PF4 levels, which decreased significantly with IPC therapy and follow-up.
IPC therapy led to a decrease in TAT concentration in PAD patients.
Von Willebrand factor (VWF) decreased significantly in the control group during and after IPC, while remaining stable in PAD patients.
Pain-free walking distance (PWD) significantly increased in PAD patients during IPC treatment.

Conclusions:

IPC is safe for PAD patients, demonstrating no pro-coagulant effects.
IPC therapy decreases platelet activation and enhances endothelial health in PAD patients.
The observed improvements in endothelial function correlate with a significant increase in walking distance.