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Updated: Jun 18, 2026
07:53
Interphase Fluorescence in situ Hybridization of Bone Marrow Smears of Multiple Myeloma
Published on: April 15, 2022
[Molecular diagnosis of malignant lymphomas]
Harald Holte1, Stein Kvaløy, Jan Delabie
1Kreftklinikken, Oslo universitetssykehus, Radiumhospitalet, Oslo, Norway. harald.holte@radiumhospitalet.no
Summary
Molecular diagnostics, using gene expression technology, identifies new subgroups of malignant lymphomas. This improves diagnostic precision and enables targeted treatments, enhancing patient outcomes.
Area of Science:
- Hematology
- Oncology
- Molecular Biology
Context:
- Malignant lymphomas are diverse non-solid tumors of lymphocytes.
- Current diagnosis relies on histopathology, immunophenotyping, and genetic analyses.
- Molecular diagnostics, particularly gene expression profiling, offers advanced insights.
Purpose:
- To describe experimental molecular diagnostics in malignant lymphomas.
- To summarize findings from an international multicenter project.
- To explore the role of gene expression technology in lymphoma diagnosis and treatment.
Summary:
- Gene expression profiling has identified novel, clinically relevant subgroups of malignant B-cell lymphomas.
- Retrospective survival analyses correlate gene expression profiles with patient outcomes.
- This biological knowledge facilitates the development of new targeted therapies.
Impact:
- Molecular diagnostics significantly enhances diagnostic precision for lymphomas.
- It opens avenues for personalized treatment strategies.
- New targeted treatments are currently under clinical investigation.
