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Related Concept Videos

Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...

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Related Experiment Video

Updated: Jun 18, 2026

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
11:02

Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy

Published on: April 13, 2022

Distribution of amelotin in mouse tooth development.

Yuguang Gao1, Wanchun Wang, Yan Sun

  • 1Department of Pediatric and Preventive Dentistry, Institute of Stomatology, Weifang Medical University, Kuiwen District, Weifang City, Shandong Province, China. yuguanggao@wfmc.edu.cn

Anatomical Record (Hoboken, N.J. : 2007)
|November 26, 2009
PubMed
Summary

Amelotin, an enamel matrix protein, is present during tooth enamel formation. This study clarifies its expression during secretion and maturation stages, confirming its role in enamel development.

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The Slice Culture Method for Following Development of Tooth Germs In Explant Culture
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Last Updated: Jun 18, 2026

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The Slice Culture Method for Following Development of Tooth Germs In Explant Culture
07:47

The Slice Culture Method for Following Development of Tooth Germs In Explant Culture

Published on: November 13, 2013

Area of Science:

  • Biochemistry
  • Developmental Biology
  • Oral Biology

Background:

  • Amelotin is secreted by ameloblasts during tooth development.
  • The precise distribution of amelotin throughout enamel development remains unclear.

Purpose of the Study:

  • To investigate the expression and distribution of amelotin during tooth enamel development.
  • To compare amelotin gene expression with other key enamel matrix proteins.

Main Methods:

  • Immunohistochemistry was used to detect amelotin protein in developing teeth.
  • Reverse transcription-polymerase chain reaction (RT-PCR) was employed to analyze gene expression in mouse mandibles.

Main Results:

  • Amelotin was identified in the enamel matrix during the secretion and maturation stages.
  • Expression was also observed at Tomes' processes of secretory ameloblasts.
  • Amelotin gene expression was detected from postnatal day 0 and co-expressed with amelogenin, enamelin, and ameloblastin.

Conclusions:

  • Amelotin is an enamel matrix protein.
  • Its expression occurs during the secretion and maturation stages of enamel development.
  • Amelotin plays a role alongside other major enamel proteins in tooth formation.