Kinetic and thermodynamic solubility values of some bioactive compounds

Area of Science:

• Drug development
• Physicochemical properties
• Analytical chemistry

Background:

• Thermodynamic solubility is critical for drug development.
• Classical solubility measurement methods can be time-consuming.
• The Chasing Equilibrium method presents a faster alternative.

Purpose of the Study:

• To evaluate the Chasing Equilibrium method for determining the solubility of acidic and basic compounds.
• To investigate the impact of experimental conditions, specifically sample weight, on solubility measurements.
• To establish optimal parameters for reliable solubility determination using this method.

Main Methods:

• Utilized the Chasing Equilibrium approach to measure thermodynamic solubility.
• Determined solubilities for a range of acidic and basic compounds.
• Conducted experiments varying sample weights to assess their effect on results.

Main Results:

• The Chasing Equilibrium method provides fast and accurate solubility data.
• Solubility measurements are sensitive to the sample weight used.
• A specific, limited range of sample weights is required for reliable results, dependent on compound properties.

Conclusions:

• The Chasing Equilibrium method is a viable and efficient alternative for solubility determination.
• Careful control of sample weight is essential for accurate and reproducible solubility data.
• This method facilitates improved drug development through precise physicochemical property assessment.