Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pressure-length loop area: its components analyzed during graded myocardial ischemia.

A Safwat1, B J Leone, R M Norris

  • 1Department of Anesthesiology, University of California, Davis.

Journal of the American College of Cardiology
|March 1, 1991
PubMed
Summary

Myocardial ischemia significantly alters left ventricular function. Effective shortening and postsystolic shortening areas change progressively during ischemia, while total loop area only decreases with marked hypokinesia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Implementing constructed wetlands for nutrient reduction at watershed scale: Opportunity to link models and real-world execution.

Journal of soil and water conservation·2024
Same author

European Reference Network for rare adult solid cancers, statement and integration to health care systems of member states: a position paper of the ERN EURACAN.

ESMO open·2021
Same author

Radiation-Induced Sarcoma: A Retrospective Population-Based Study Over 34 Years in a Single Institution.

Clinical oncology (Royal College of Radiologists (Great Britain))·2021
Same author

Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network.

Annals of oncology : official journal of the European Society for Medical Oncology·2020
Same author

Serum Biomarkers as Prognostic Factors for Metastatic Sarcoma.

Clinical oncology (Royal College of Radiologists (Great Britain))·2019
Same author

Adipose mesenchymal stem cells-derived exosomes attenuate retina degeneration of streptozotocin-induced diabetes in rabbits.

Journal of circulating biomarkers·2018

Area of Science:

  • Cardiovascular Physiology
  • Cardiac Mechanics
  • Myocardial Ischemia Research

Background:

  • Assessing left ventricular (LV) function during myocardial ischemia is crucial for understanding cardiac disease.
  • Pressure-length loops provide a comprehensive measure of cardiac mechanics.
  • Regional dysfunction during ischemia impacts overall LV performance.

Purpose of the Study:

  • To compare changes in pressure-length loop areas with varying degrees of myocardial ischemia.
  • To investigate the relationship between ischemia-induced regional dysfunction and LV pressure-loop parameters.

Main Methods:

  • Seven anesthetized dogs underwent instrumentation for LV pressure and regional wall motion (sonomicrometry) measurement.
  • Myocardial ischemia was induced in the left anterior descending coronary artery territory.

Related Experiment Videos

  • Pressure-length loops were analyzed for total area, effective shortening, systolic lengthening, and postsystolic shortening areas under varying ischemia and afterload conditions.

    • Main Results:

    • Total pressure-length loop area decreased significantly only at moderate ischemia (marked hypokinesia).
    • Effective shortening area progressively decreased with increasing ischemia severity.
    • Postsystolic shortening area significantly increased with each stage of ischemia, indicating impaired relaxation and contractile function.

    Conclusions:

    • Postsystolic shortening area is a sensitive indicator of early regional dysfunction during myocardial ischemia.
    • Effective shortening area reflects the overall impact of ischemia on LV systolic function.
    • Total loop area is a less sensitive marker for early to moderate ischemia but reflects severe dysfunction.