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Updated: Jun 18, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
[Alkaloids from Dactylicapnos scandens Hutch]
Fuhua Wang1, Xiao Hu, Hailin Chen
1School of Pharmacy, Fudan University, Shanghai 201203, China.
Objective:
To investigate the alkaloids in the roots of Dactylicapnos scanden (D. Don) Hutch.
Method:
The compounds were isolated by various column chromatographic methods. The structures were elucidated by spectroscopic analysis.
Result:
Eight compounds were isolated and identified as d-isocorydine (1), protopine (2), d-magnoflorine (3), d-isocorydine-beta-N-oxide (4), d-corydine-alpha-N-oxide (5), d-corydine-beta-N-oxide (6), 6S, 6aS-N-methyllaurotetanine-alpha-N-oxide (7), and 6R, 6aS-N-methyllaurotetanine-beta-N-oxide (8).
Conclusion:
Compounds 4-8 were isolated from this species and the genus Dactylicapnos for the first time.
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