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LncRNA-ATB Orchestrates Tumor Growth and Immune Responses Through the Modulation of IGF2BP2 in Non-Small-Cell Lung
Shifang Sun1, Hailin Chen2, Shanshan Rong2
1Department of Geriatrics, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo, China.
Abstract:
Long non-coding RNAs (lncRNAs) are known to play a vital role in regulating tumorigenesis. Previous studies have shown that long non-coding RNA modulated by transforming growth factor-beta (lncRNA-ATB) is overexpressed in non-small-cell lung cancer (NSCLC); however, the underlying mechanism of lncRNA-ATB as an oncogenic regulator remains elusive. This study elucidates the effect of lncRNA-ATB on cell proliferation, migration, and invasion of NSCLC cell lines (A549 and H522) and triggers cellular immune responses. The tumor microenvironment was simulated in BALB/c mice, and the in vivo pro-tumor effect of lncRNA-ATB was discovered. This study further explores the molecular mechanisms of lncRNA-ATB-mediated effects. The interaction of lncRNA-ATB with insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) has been found, and IGF2BP2 can play a role in tumor immune cell infiltration and tumor cell proliferation by stabilizing lncRNA-ATB. In conclusion, lncRNA-ATB plays a complex regulatory role in the progression of NSCLC and may serve as a potential target for future treatment. This study provides valuable insights into the complex interactions of lncRNAs in the pathogenesis of NSCLC, and the robust methodology and comprehensive analysis presented in this study contribute to advancing our understanding of the molecular mechanisms underlying NSCLC progression.
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