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Tryptase is not cleared by the kidneys into the urine
Michael R Simon1, Mindy Jan, Jerry Yee
1Allergy and Immunology Section, William Beaumont Hospital, Royal Oak, MI 48073, USA. mrsimonmd@sbcglobal.net
International Archives of Allergy and Immunology
|November 27, 2009
Summary
Tryptase is not filtered by the kidneys. Studies show that tryptase, an enzyme, is not detected in urine, even in concentrated samples from healthy individuals and those with systemic mastocytosis.
Area of Science:
- Biochemistry
- Nephrology
- Immunology
Background:
- Elevated blood tryptase levels are observed in patients with chronic kidney disease.
- Tryptase has been previously detected in the urine of healthy individuals.
Purpose of the Study:
- To investigate the renal clearance of tryptase.
- To determine if the kidneys excrete tryptase into the urine.
Main Methods:
- Blood and urine samples were collected from healthy subjects and patients with systemic mastocytosis.
- Concentrations of total and mature tryptase in blood and total tryptase in urine were measured.
Main Results:
- Urine tryptase levels were below the limit of detection (<0.2 ng/ml) in all participants, even after urine concentration.
- Neither mature nor precursor tryptase forms were found in the urine.
Conclusions:
- Tryptase is not cleared by the kidneys.
- Renal excretion of tryptase does not occur.
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