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Updated: Jun 18, 2026

Structure and Coordination Determination of Peptide-metal Complexes Using 1D and 2D 1H NMR
Published on: December 16, 2013
Synthesis, characterization, bioactivities of copper complexes with N-allyl di(picolyl)amine
Qiu-Yun Chen1, Hai-Jian Fu, Juan Huang
1School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang, PR China. chenqy@ujs.edu.cn
Abstract:
Four copper(II) complexes with N-allyl di(picolyl)amine were synthesized and characterized by physico-chemical and spectroscopic methods. The spectrophotometric and fluorescence titration data indicate that the [(Aldpa)Cu(L)](ClO(4))(2) (L=dppz, dione, phen) with conjugated aromatic rings as coordinated ligands can be inserted into the base stacks of DNA more deeply than the [(Aldpa)CuCl(2)]. The copper(II) complexes [(Aldpa)Cu(L)](ClO(4))(2) (L=dppz, dione, phen) can inhibit the proliferation of the four cancer cells (Mcf-7, Eca-109, A549 and HeLa) with IC(50) 0.5-19.2 microM, which is larger than that (23.2-84.3 microM) of [(Aldpa)CuCl(2)], suggesting their inhibiting activities on the four cancer cells are correlated with their DNA-binding properties. However, the selectivity of [(Aldpa)CuCl(2)] to cancer cells is better than that of the other three complexes [(Aldpa)Cu(L)](ClO(4))(2), which indicates the substituents introduced on the secondary amino nitrogen atom of dpa have great contribution to the antitumor activities of these copper(II) complexes.
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