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Updated: Jun 18, 2026

Electrophoretic Delivery of γ-aminobutyric Acid (GABA) into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
[Endocrine and metabolic effects of antiepileptic drugs]
Luis Gustavo C Bortolini1, Carolina A M Kulak, Victoria Z C Borba
1Hospital das Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil.
Abstract:
The antiepileptic drugs (AED) have been widely used for a great deal of people--in the treatment of epilepsy and other diseases--throughout the world. Continuous and prolonged use of AED may be associated with adverse effects in different systems, including a variety of endocrine and metabolic abnormalities. In this review, the relationship of AED with alterations in bone mineral metabolism, energy balance and body weight, gonadal function and thyroid metabolism was revised, as well as their clinical utility in the treatment of diabetic neuropathy.
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