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Forward Genetic Approach to Uncover Stress Resistance Genes in Mice — A High-throughput Screen in ES Cells
Published on: November 11, 2015
Longevity in mice: is stress resistance a common factor?
1Department of Pharmacology, Physiology and Therapeutics, University of North Dakota School of Medicine and Health Sciences, 501 North Columbia Road, Grand Forks, ND 58203, USA. brownbrg@medicine.nodak.edu
Age (Dordrecht, Netherlands)
|November 28, 2009
Summary
Long-lived mice, including genetically altered and dwarf models, show increased stress resistance. These findings link enhanced stress resilience to extended lifespan, impacting our understanding of aging.
Area of Science:
- Gerontology
- Genetics
- Molecular Biology
Background:
- A positive correlation between stress resistance and longevity is observed across various species.
- Several mouse models with extended lifespans have been identified, offering insights into aging processes.
Purpose of the Study:
- To review and describe long-living mouse models, focusing on their extended lifespans and stress resistance.
- To compare genetically altered long-living mice with those affected by caloric restriction (CR).
Main Methods:
- Literature review of studies on genetically modified and naturally occurring long-living mouse lines.
- Analysis of reported lifespans and stress resistance assays in these mouse models.
- Brief discussion of caloric restriction (CR) effects on stress resistance and longevity.
Main Results:
- Multiple mouse lines, such as Ames dwarf and Klotho transgenic mice, exhibit significantly extended lifespans.
- Enhanced resistance to oxidative stress is a common feature in most long-living mouse models.
- Some long-living mice show life extension without clear links to growth hormone/IGF-1/insulin signaling pathways.
Conclusions:
- Long-living mice often display enhanced stress resistance, particularly to oxidative stress.
- The mechanisms underlying extended lifespan in these models involve complex interactions coordinating growth and metabolism.
- These models provide valuable tools for studying the interplay between stress resistance and aging.
