Related Experiment Video
Updated: Jun 18, 2026

Synthesis and Characterization of mRNA-Loaded Poly(Beta Aminoesters) Nanoparticles for Vaccination Purposes
Published on: August 13, 2021
DNA vaccines for biodefense
Lesley C Dupuy1, Connie S Schmaljohn
1Heaadquauarters, Unnited Staates Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA. lesley.dupuy@amedd.army.mil
Abstract:
An ideal biodefense vaccine platform would allow for the quick formulation of novel vaccines in response to emerging or engineered pathogens. The resultant vaccine should elicit protective immune responses in one to three doses and be unaffected by pre-existing immunity to vaccine components. In addition, it should be amenable to combination and multi-agent formulation, and should be safe for all populations and the environment. DNA vaccines can potentially meet all of these requirements; thus, this platform is being tested with several biodefense threats. Here, we provide a review of the current status of the development efforts for DNA vaccines against several relevant biodefense pathogens: Bacillus anthracis, Ebola and Marburg viruses, smallpox virus, and Venezuelan equine encephalitis virus.
Related Concept Videos
Vaccines
Vaccinations
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Smallpox
Vaccine Production
Cross-reactivity

