Related Experiment Video
Updated: Jun 18, 2026

Early Detection of Drug-Induced Renal Hemodynamic Dysfunction Using Sonographic Technology in Rats
Published on: March 11, 2016
Monitoring renal function in hypertensive pregnancy
Anne-Marie Côté1, Elaine M Lam, Peter von Dadelszen
1Department of Nephrology, University of Sherbrooke, Sherbrooke, PQ, Canada.
Objective:
In hypertensive pregnancy, to compare 24hr creatinine clearance (CrCl) with formulae-derived renal function (Cockcroft-Gault (CG) or Modified Diet in Renal Disease (MDRD)).
Study Design:
Retrospective review (198 women, 63% preeclampsia) using paired t-test (significant p < 0.008) and intraclass correlation coefficients (acceptable >0.70) to compare 24hr and CG CrCl. The 24hr CrCl was compared with each of the CG and MDRD formulae by Bland-Altman plots.
Results:
For 24hr CrCl, uncorrected values were similar to corrected using pre-pregnancy weight (p = 0.04); other weights gave consistently different CrCl (p < 0.0001). Limits of agreement were wide when CG and MDRD formulae were compared with 24hr CrCl. Compared with 24hr CrCl, MDRD estimates were consistently lower, and CG CrCl higher (current weight) or lower (pre-pregnancy or lean weight).
Conclusion:
MDRD and CG formulae should not be used in hypertensive pregnancy. Use of serum creatinine is advocated. If 24hr CrCl is performed, any correction should utilize pre-pregnancy weight. Neither the Cockcroft-Gault nor Modified Diet in Renal Disease formulae for glomerular filtration rate estimation are alternatives to 24hr creatinine clearance in hypertensive pregnancy.
Related Concept Videos
Hormonal Regulation
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Chronic Kidney Disease III: Interprofessional Care
Chronic Kidney Disease IV: Nursing Management
Factors Affecting Renal Clearance: Renal Impairment
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Hypertension III: Clinical Manifestations and Diagnostic Studies