Difficulties in recruiting older people in clinical trials: an examination of barriers and solutions

Area of Science:

• Gerontology
• Clinical Research Methodology
• Public Health

Background:

• Optimal recruitment and retention of older adults in clinical trials remain under-researched.
• Older populations are crucial for clinical trial generalizability but face unique participation barriers.

Purpose of the Study:

• To identify common barriers hindering the recruitment of older individuals into clinical trials.
• To propose evidence-based solutions for overcoming these recruitment challenges.

Main Methods:

• A comprehensive literature review was conducted to identify recruitment difficulties.
• Real-world experiences from a randomized control trial recruitment process were integrated.

Main Results:

• Numerous barriers to recruiting older adults were identified through literature and practical experience.
• Key challenges include complex consent procedures and inadequate communication strategies.

Conclusions:

• Population-specific recruitment strategies are essential for older adults.
• Simplifying informed consent and enhancing researcher-participant communication are vital for successful trial engagement.