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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Updated: Jun 18, 2026

Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis
09:44

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Pediatric inflammatory bowel disease: highlighting pediatric differences in IBD.

Cary G Sauer1, Subra Kugathasan

  • 1Department of Pediatrics, Emory University School of Medicine, Emory Children's Center, 2015 Uppergate Drive, Atlanta, GA 30322, USA.

The Medical Clinics of North America
|December 1, 2009
PubMed
Summary

Pediatric inflammatory bowel disease (IBD) offers insights into disease origins. Understanding early-onset IBD, including Crohn disease and ulcerative colitis, may reveal crucial information for prevention and treatment strategies.

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Area of Science:

  • Gastroenterology
  • Pediatric Medicine
  • Immunology

Background:

  • Inflammatory bowel disease (IBD), encompassing Crohn disease and ulcerative colitis, is frequently diagnosed in late childhood and early adulthood.
  • The factors influencing the age of IBD onset are not yet understood.
  • Early-onset IBD may represent a less complicated form of the disease, potentially holding keys to its initial pathogenesis.

Purpose of the Study:

  • To discuss clinically relevant epidemiology and treatment of pediatric IBD.
  • To highlight similarities and differences between pediatric and adult-onset IBD.
  • To emphasize evidence-based treatment algorithms for pediatric IBD.

Main Methods:

  • Review of recent pediatric IBD studies.
  • Comparative analysis of pediatric and adult IBD data.
  • Focus on clinical epidemiology and treatment strategies.

Main Results:

  • Pediatric IBD studies reveal numerous similarities and differences compared to adult-onset IBD.
  • The underlying mechanisms for these observed similarities and differences remain unclear.
  • Data contributes to a more complex understanding of IBD.

Conclusions:

  • Pediatric IBD is a critical area of research for understanding IBD pathogenesis.
  • Further investigation is needed to elucidate the mechanisms behind age-related variations in IBD.
  • Focus on pediatric data can inform prevention and treatment for this lifelong condition.