Related Experiment Video

Updated: Jun 18, 2026

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

Genomic and proteomic analysis of myocarditis and dilated cardiomyopathy

Leslie T Cooper1, Oyere K Onuma, Sandeep Sagar

  • 1Mayo Clinic College of Medicine, Rochester, MN 55905, USA. cooper.leslie@mayo.edu

Heart Failure Clinics
|December 1, 2009
PubMed

Insights

Myocarditis, an inflammation of the heart muscle, can lead to dilated cardiomyopathy (DCM). Advanced screening techniques are uncovering new ways to understand and treat this condition.

Area of Science:

  • Cardiology
  • Genomics
  • Proteomics

Background:

  • Myocarditis is myocardial inflammation causing cardiac myocyte injury.
  • It is a potential cause of idiopathic dilated cardiomyopathy (DCM) due to viral persistence.
  • Novel screening techniques offer insights into disease pathogenesis.

Purpose of the Study:

  • To review noncandidate genomic and proteomic screening strategies.
  • To discuss their application in evaluating myocarditis and nonischemic DCM.
  • To highlight potential strengths and limitations of these approaches.

Main Methods:

  • Utilizing genome and proteome screening techniques.
  • Applying methods that do not require prior mechanistic knowledge of disease.
  • Analyzing disease-specific profiles revealed by these screenings.

Main Results:

  • Screening techniques are identifying novel disease mechanisms.
  • Biomarkers for myocarditis and DCM are being discovered.
  • Potential therapeutic targets are emerging from these studies.

Conclusions:

  • Noncandidate genomic and proteomic screening are valuable tools.
  • These methods aid in understanding myocarditis and nonischemic DCM.
  • Careful consideration of strengths and pitfalls is necessary for effective evaluation.

More Related Videos

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse12:24

Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse

Published on: June 20, 2014

Related Concept Videos

Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...