Related Experiment Video

Updated: Jun 18, 2026

Combined DNA-RNA Fluorescent In situ Hybridization (FISH) to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells
15:54

Combined DNA-RNA Fluorescent In situ Hybridization (FISH) to Study X Chromosome Inactivation in Differentiated Female Mouse Embryonic Stem Cells

Published on: June 14, 2014

X chromosome inactivation: when dosage counts

Elphège P Nora1, Edith Heard

  • 1Institut Curie, CNRS UMR3215, INSERM U934, 75724 Paris Cedex 05, France.

Cell
|December 1, 2009
PubMed
Summary

Mammals ensure only one X chromosome is active by using Rnf12/RLIM. This protein triggers X chromosome inactivation when its levels exceed a threshold, which occurs with multiple active X chromosomes.

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