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Updated: Jun 18, 2026

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management
Published on: November 21, 2017
Pediatric emergencies associated with fever
Ilene Claudius1, Larry J Baraff
1Department of Emergency Medicine, University of Southern California and Children's Hospital, 1200 State Street 1011, Los Angeles, CA 90033, USA.
Insights
Fever in infants requires prompt evaluation, especially in neonates and those with risk factors like sickle cell disease. Early identification and management of serious infections, including MRSA and HSV, are crucial for preventing severe outcomes.
Area of Science:
- Pediatrics
- Infectious Diseases
- Emergency Medicine
Background:
- Fever is a common pediatric symptom, defined as a rectal temperature >38.0°C (100.4°F).
- Home-documented fevers require similar management as those in the Emergency Department (ED).
- Certain populations, including neonates and children with sickle cell disease, are at higher risk for serious febrile illness.
Purpose of the Study:
- To outline the evaluation and management of pediatric fever.
- To identify high-risk populations and specific pathogens requiring urgent attention.
- To emphasize the importance of considering less common but serious causes of fever.
Main Methods:
- Review of current guidelines and literature on pediatric fever management.
- Discussion of diagnostic criteria for sepsis workup in infants.
- Highlighting clinical and laboratory indicators for risk stratification.
Main Results:
- Febrile infants <28 days old require a full sepsis workup and parenteral antibiotics.
- Low-risk infants aged 1-4 months can be identified using clinical/laboratory criteria.
- Consideration of Methicillin-resistant Staphylococcus aureus (MRSA) and Herpes Simplex Virus (HSV) infections is essential.
Conclusions:
- Prompt and appropriate management of pediatric fever is critical.
- Risk stratification aids in determining the intensity of workup and treatment.
- Awareness of specific pathogens like MRSA and HSV improves patient outcomes.
Abstract:
Fever is defined as a rectal temperature greater than 38.0 degrees C (>100.4 degrees F). A recently documented fever at home should be considered the same as a fever in the ED and should be managed similarly. All febrile infants younger than 28 days should receive a "full sepsis workup" and be admitted for parenteral antibiotic therapy. Clinical and laboratory criteria can be used to identify a low-risk population of febrile infants aged 1 to 4 months who have not received 2 doses of conjugate vaccines for bacterial meningitis. Children with sickle cell disease are at high risk and require special evaluation. MRSA infections are now common and should be considered in all patients with pyoderma, severe pneumonia, and catheter-related sepsis. HSV infection of the CNS should be considered whenever a patient has altered mental status and CSF findings are not diagnostic of bacterial meningitis. Fever rarely represents life-threatening pathology; however, a handful of less common serious causes of pediatric fever exist with the potential for morbidity and mortality.
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