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A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
Published on: April 26, 2015
Epinephrine Improves Outcomes in Out-Of-Hospital Cardiac Arrests
Tarlan Hedayati1, Ari Edelheit1
1Department of Emergency Medicine, Rush University Medical College, Chicago, IL, USA; Department of Emergency Medicine, Cook County Hospital, Chicago, IL, USA.
Abstract:
Epinephrine use in cardiac arrest (CA) is associated with a greater likelihood of return of spontaneous circulation (ROSC) but this early potential benefit does not seem to translate to survival with good neurologic outcomes. Similarly, high-dose epinephrine may yield a small increase in ROSC but does not improve rates of hospital discharge, long-term survival, or improved neurologic outcomes compared to standard-dosed epinephrine. Higher cumulative doses of epinephrine (>3 mg) during CA has been consistently associated with poor neurologic outcomes following ROSC.
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