Related Experiment Video
Updated: Jun 26, 2026

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
Published on: December 27, 2016
Cephalosporins Should be Avoided in Patients with Penicillin Allergy
1Department of Emergency Medicine, Lancashire Teaching Hospitals, Sharoe Green Lane, Preston, PR2 9HT, UK.
Abstract:
There has long been concern regarding cross-reactivity between penicillin and cephalosporin allergies, with historical sources citing rates up to 10%. More recent assessment of later-generation cephalosporins suggests a cross-reactivity rate closer to 1%. Clinical guidance is inconsistent, with some advising blanket avoidance of cephalosporins, whereas more recent specialist guidance supports a nuanced, risk-stratified approach. Shared decision-making and individual risk assessment are recommended, with a role for formal allergy testing and incremental dosing in some cases.
Related Concept Videos
Inhibitors of Gram-positive Cell Wall Synthesis
Production of Antibiotics
Cryptococcal Meningitis
Allergic Reactions: Anaphylaxis
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Hypersensitivity Reactions: Cytolytic Reactions