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Related Concept Videos

Fibril-associated Collagen01:11

Fibril-associated Collagen

Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
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Type IV collagen is a 400 nm long, network-forming collagen that acts as a barrier between the epithelial and endothelial cells. Type IV collagen  forms the backbone of the basement membrane by scaffolding with laminin, entactin, proteoglycans, and fibronectin. Apart from rendering structural support to the basement membrane, it also helps entail signaling potentials necessary for both pathological and physiological functions.
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Tissue Engineering of Tumor Stromal Microenvironment with Application to Cancer Cell Invasion
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Collagen XVII.

Cristina Has1, Johannes S Kern

  • 1Department of Dermatology, University Medical Center Freiburg, Hauptstr. 7, 79104 Freiburg, Germany. cristina.has@uniklinik-freiburg.de

Dermatologic Clinics
|December 1, 2009
PubMed
Summary
This summary is machine-generated.

Collagen XVII is crucial for skin integrity, anchoring epithelial cells to the basement membrane. Its dysfunction causes genetic blistering disorders like junctional epidermolysis bullosa non-Herlitz.

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Area of Science:

  • Dermatology
  • Cell Biology
  • Genetics

Background:

  • Collagen XVII is a key structural protein in hemidesmosomes.
  • Hemidesmosomes anchor epithelial cells to the basement membrane.
  • Collagen XVII plays a role in dermal-epidermal adhesion.

Purpose of the Study:

  • To examine the genetic and pathological features of Collagen XVII.
  • To highlight the relevance of Collagen XVII in blistering disorders.

Main Methods:

  • Review of genetic and pathological data related to Collagen XVII.
  • Analysis of Collagen XVII's structural role in hemidesmosomes.

Main Results:

  • Collagen XVII is implicated in inherited junctional epidermolysis bullosa non-Herlitz.
  • The protein's role extends to autoimmune blistering conditions.
  • Collagen XVII is essential for maintaining epithelial cell anchorage.

Conclusions:

  • Collagen XVII is vital for dermal-epidermal adhesion.
  • Genetic defects in Collagen XVII lead to severe skin blistering diseases.
  • Understanding Collagen XVII's function is critical for treating related disorders.