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Updated: Jun 18, 2026

Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Understanding the pathogenesis of recessive dystrophic epidermolysis bullosa squamous cell carcinoma
Andrew P South1, Edel A O'Toole
1Centre For Oncology and Molecular Medicine, Ninewell's Hospital and Medical School, Dundee, DD1 9SY, UK. a.p.south@dundee.ac.uk
Abstract:
Patients with recessive dystrophic epidermolysis bullosa develop numerous life-threatening skin cancers. The reasons for this remain unclear. Parallels exist with other scarring skin conditions, such as Marjolin ulcer. We summarize observational and experimental data and discuss proposed theories for the development of such aggressive skin cancers. A context-driven situation seems to be emerging, but more focused research is required to elucidate the pathogenesis of epidermolysis bullosa-associated squamous cell carcinoma.
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