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Updated: Jun 18, 2026

Venous Thrombosis Assay in a Mouse Model of Cancer
Published on: January 5, 2024
Recurrent thromboflebitis as a warning sign for cancer: a case report
Henk C P M van Weert1, Francien Pingen
1Academic Medical Centre Amsterdam, Dpt General Practice Meibergdreef 15, 1105 AZ Amsterdam, the Netherlands. h.c.vanweert@amc.uva.nl
Introduction:
The association between unprovoked deep venous thrombosis or pulmonary embolism and malignancy is well established. For unprovoked superficial thrombophlebitis this association has been documented in a few case-reports only.
Case Presentation:
A 54-year-old apparently healthy male presents for the fourth time with an unprovoked superficial thrombophlebitis of the leg. When screened for underlying causes a renal cell carcinoma and an adenocarcinoma of the prostate are diagnosed. The renal cell carcinoma pointed out to have been visible on a CT-scan, made just before the time of the first presentation of the thrombophlebitis.
Conclusion:
Unprovoked and recurrent thrombophlebitis is a rare condition and its presentation might be a warning sign for a (yet undiagnosed) cancer. Physicians should be on their guard and consider screening for cancer. Usefulness of such a screening however is not known.
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