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Neo-Clerodane Diterpenes from Ajuga turkestanica
Mary H Grace1, Diana M Cheng, Ilya Raskin
1Department of Natural Resources and Environmental Sciences, University of Illinois, Urbana, IL 61801, USA.
Abstract:
The ethyl acetate extract of the aerial parts of Ajuga turkestanica afforded 6 neo-clerodane diterpenes, including two novel compounds, 14, 15-dihydroajugachin B (1) and 14-hydro-15-methoxyajugachin B (2), in addition to the known diterpenoids chamaepitin (3), ajugachin B (4), ajugapitin (5) and lupulin A (6). Structures were established through exhaustive NMR spectroscopic analysis and chemical transformation in the case of 1. The full (1)H and (13)C NMR assignment of the C-15 R and S configurations of 14-hydro-15-methoxyajugachin B and chamaepitin were elucidated.
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