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Updated: Jun 18, 2026
05:16
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
Published on: August 4, 2021
Etiologic characterization of recurrent miscarriages in Koreans
Gyun-Ho Jeon1, So-Ra Kim, Sung-Hoon Kim
1Department of Obstetrics and Gynecology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.
The Journal of Reproductive Medicine
|December 2, 2009
Summary
Recurrent miscarriage causes in Koreans differ from Western data, with anatomical abnormalities being most common. Successful pregnancy rates are higher for secondary recurrent miscarriage cases compared to primary ones.
Area of Science:
- Reproductive Medicine
- Obstetrics & Gynecology
- Clinical Epidemiology
Background:
- Recurrent miscarriage (RM) affects a significant portion of women, impacting reproductive outcomes.
- Understanding ethnic-specific etiological factors and prognosis is crucial for effective management.
Purpose of the Study:
- To identify the primary causes of recurrent miscarriage in the Korean population.
- To compare the prognosis for subsequent successful pregnancies in primary versus secondary recurrent miscarriage cases.
Main Methods:
- Retrospective analysis of 222 recurrent miscarriage cases from July 1989 to June 2008.
- Classification of cases based on identified etiological factors.
- Comparison of successful pregnancy rates between primary and secondary RM groups using chi-squared test.
Main Results:
- Anatomical abnormalities were the leading cause (29.4%), followed by immunologic (26.7%), inexplicable (24.1%), endocrinologic (15.0%), and genetic (11.2%) factors.
- The successful pregnancy rate was significantly higher in the secondary RM group (47.9%) compared to the primary RM group (31.7%) (p < 0.05).
Conclusions:
- The etiological profile of recurrent miscarriage in Koreans differs from Western populations.
- Secondary recurrent miscarriage cases demonstrate a better prognosis for subsequent successful pregnancies.
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