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Serum homocysteine in deep venous thrombosis, peripheral atherosclerosis and healthy Iranians: a case-control study

H Ravari1, M R Zafarghandi, D Alvandfar

  • 1Iman Reza Hospital, Mashhad University of Medical Sciences, Iran.

Pakistan Journal of Biological Sciences : PJBS
|December 2, 2009
PubMed

Insights

This study found no clear link between high homocysteine and peripheral atherosclerosis or deep vein thrombosis in Iranians. Unexpectedly high homocysteine levels were observed in the general population, suggesting potential benefits from food fortification.

Area of Science:

  • Vascular Medicine
  • Biochemistry
  • Epidemiology

Background:

  • Elevated serum homocysteine is a potential risk factor for vascular diseases.
  • The association between homocysteine and peripheral atherosclerosis or deep vein thrombosis (DVT) requires further investigation in diverse populations.

Purpose of the Study:

  • To evaluate the association between serum homocysteine levels and peripheral atherosclerosis and DVT.
  • To assess homocysteine levels in an Iranian population with vascular symptoms.

Main Methods:

  • A case-control study was conducted with 25 patients each for DVT and atherosclerosis, and 25 controls.
  • Diseases were confirmed using duplex ultrasonography for DVT and angiography for atherosclerosis.
  • Serum homocysteine levels were measured and compared across groups.

Main Results:

  • Serum homocysteine levels were higher in males, except in atherosclerotic patients.
  • Prevalence of high homocysteine varied: 15% (control), 36% (DVT), 56% (atherosclerosis) in females; 75% (control), 73% (DVT), 56% (atherosclerosis) in males.
  • The control group, representing the general Tehran population without vitamin B supplements, showed unexpectedly high homocysteine levels.

Conclusions:

  • The study did not confirm a significant association between homocysteine and atherosclerosis or DVT in this Iranian population, particularly in men.
  • High prevalence of hyperhomocysteinemia in the general population may obscure the association.
  • Consideration of fortification of staple foods with vitamin B in Tehran is suggested.

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