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Related Concept Videos

Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
Prescription, Nonprescription and Orphan Drugs01:02

Prescription, Nonprescription and Orphan Drugs

Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...
Prevention of Further Absorption of Poison01:14

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In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
Drug Toxicity: Overview01:00

Drug Toxicity: Overview

Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...

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A Whole Mount In Situ Hybridization Method for the Gastropod Mollusc Lymnaea stagnalis
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Danger in your pill bottle?

Scott Strassels1

  • 1Division of Pharmacy Practice, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA. scotts1@mail.utexas.edu

Journal of Pain & Palliative Care Pharmacotherapy
|December 2, 2009
PubMed
Summary
This summary is machine-generated.

This commentary argues that opioid use is not inherently dangerous and supports rational pain management. It emphasizes balancing risks and benefits, using federal data for perspective.

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Area of Science:

  • Pain Management
  • Pharmacology
  • Public Health

Background:

  • Concerns exist regarding the inherent dangers of opioid use.
  • Published assertions often discourage opioid utilization.
  • A balanced perspective on opioid therapy is needed.

Purpose of the Study:

  • To refute claims of inherent danger in opioid use.
  • To present a reasoned case for risk-to-benefit analysis in opioid therapy.
  • To support the rational application of opioids in pain management.

Main Methods:

  • Literature review and commentary.
  • Analysis of federal reporting systems data.
  • Risk-to-benefit assessment framework.

Main Results:

  • Published assertions on opioid danger are challenged.
  • Federal data provides context for opioid risk assessment.
  • Rational use of opioids in pain management is supported.

Conclusions:

  • Opioid use requires careful risk-to-benefit consideration, not outright discouragement.
  • Rational prescribing practices are crucial for effective pain management.
  • Evidence-based perspectives are essential for informed opioid therapy decisions.