Related Experiment Video
Updated: Jun 18, 2026

Co-immunoprecipitation Assay Using Endogenous Nuclear Proteins from Cells Cultured Under Hypoxic Conditions
Published on: August 2, 2018
Regulation of hypoxia-inducible genes by PGC-1 alpha
1Harvard Medical School, Boston, MA 02115, USA.
Abstract:
Atmospheric oxygen appeared approximately 2.3 billion years ago and sustains most complex life on earth. As mitochondria evolved to harness the energy in oxygen, systems developed to sense and respond to local oxygen concentrations and metabolic conditions. For more than a decade, research has focused on hypoxia-inducible factor 1 (HIF1), a key component of the eukaryotic oxygen-response system. Recently, evidence for other systems has also surfaced. One of these systems involves the PGC-1 alpha coactivator, a powerful transcriptional regulator of mitochondria and oxidative metabolic programs. This brief review will focus on this burgeoning role for PGC-1 alpha and will highlight the many questions that remain unanswered.
Related Concept Videos
Regulation of Angiogenesis and Blood Supply
Cell Specific Gene Expression
Hypoxia
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Master Transcription Regulators
Master Transcription Regulators
General Transcription Factors

