Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low-Cost Approaches in Neuroscience to Teach Machine Learning Using a Cockroach Model.

eNeuroĀ·2024
Same author

The NEURON Program: Utilizing Low-Cost Neuroscience for Remote Education Outreach.

Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate NeuroscienceĀ·2023
Same author

A low-cost computational approach to analyze spiking activity in cockroach sensory neurons.

Advances in physiology educationĀ·2021
Same author

Early-life ketamine exposure attenuates the preference for ethanol in adolescent Sprague-Dawley rats.

Behavioural brain researchĀ·2020
Same author

Self-Contained Statistical Analysis of Gene Sets.

PloS oneĀ·2016
Same author

Modeling Honey Bee Populations.

PloS oneĀ·2015
Same journal

Neural-behavioral dissociation under acute high-altitude stress: an exploratory ERP study of non-specific neural recruitment and rTMS effects.

Frontiers in behavioral neuroscienceĀ·2026
Same journal

Assessing circuit function in the developing <i>Xenopus</i> tadpole: a survey of the behavioral toolkit and underlying neural substrates.

Frontiers in behavioral neuroscienceĀ·2026
Same journal

Dawn of the dread: threatening cinematic virtual reality environments enhance general but not specific pavlovian-instrumental transfer.

Frontiers in behavioral neuroscienceĀ·2026
Same journal

Transcranial alternating current stimulation improves cognitive functions in healthy subjects through modifying frontoparietal and dorsal attention networks based on personalized individual theta frequency analysis.

Frontiers in behavioral neuroscienceĀ·2026
Same journal

Functional loss of PKMĪ¶ in the dorsal hippocampus potentiates the time-dependent increase in false contextual fear memory and impairs spatial recognition memory in mice.

Frontiers in behavioral neuroscienceĀ·2026
Same journal

Distinct orbitofrontal circuits with dorsal and ventral CA1 differentially regulate spatial memory and emotional behaviors.

Frontiers in behavioral neuroscienceĀ·2026
See all related articles

Related Experiment Video

Updated: Jun 18, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

Local hippocampal methamphetamine-induced reinforcement.

Ulises M Ricoy1, Joe L Martinez

  • 1Department of Biology, University of Texas at San Antonio San Antonio, TX, USA. ricoyu@ohsu.edu

Frontiers in Behavioral Neuroscience
|December 2, 2009
PubMed
Summary
This summary is machine-generated.

Methamphetamine (METH) addiction research often overlooks the hippocampus. This study demonstrates METH induces drug-seeking and taking behaviors in rats via hippocampal dopamine receptor activation, suggesting its role in addiction.

Keywords:
hippocampusmethamphetaminereward

More Related Videos

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats
04:11

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

Published on: November 6, 2018

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus
09:36

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus

Published on: September 9, 2020

Related Experiment Videos

Last Updated: Jun 18, 2026

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats
04:11

A Conditioned Place Preference Protocol for Measuring Incubation of Craving in Rats

Published on: November 6, 2018

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus
09:36

Combined In Vivo Anatomical and Functional Tracing of Ventral Tegmental Area Glutamate Terminals in the Hippocampus

Published on: September 9, 2020

Area of Science:

  • Neuroscience
  • Addiction Research
  • Neuropharmacology

Background:

  • Drug abuse, particularly methamphetamine (METH) use, is a significant public health issue.
  • The hippocampus, crucial for learning and memory, is understudied in addiction research compared to areas like the nucleus accumbens (NAc), ventral tegmental area (VTA), and prefrontal cortex (PFC).

Purpose of the Study:

  • To investigate the role of the hippocampus in methamphetamine-induced addiction.
  • To explore whether hippocampal dopamine receptor activation mediates METH-seeking and METH-taking behaviors.

Main Methods:

  • Rats received unilateral microdialysis of METH into the dorsal hippocampus.
  • Drug-seeking behavior was assessed using a place preference paradigm.
  • Drug-taking behavior was measured by lever-pressing.
  • The effect of a selective D(1)/D(5) receptor antagonist on these behaviors was evaluated.

Main Results:

  • Hippocampal METH administration induced significant place preference and lever-pressing behavior in rats.
  • These METH-induced behaviors were dose-dependently attenuated by a selective D(1)/D(5) receptor antagonist.
  • Dopamine (DA) receptor activation within the hippocampus is critical for METH reinforcement.

Conclusions:

  • The hippocampus plays a previously underappreciated role in the neural circuitry of drug addiction.
  • Targeting hippocampal dopamine receptors may offer novel therapeutic strategies for methamphetamine addiction.