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Expression and function of p-glycoprotein in normal tissues: effect on pharmacokinetics

Frantisek Staud1, Martina Ceckova, Stanislav Micuda

  • 1Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Kralove, Charles University in Prague, Hradec Kralove, Czech Republic. frantisek.staud@faf.cuni.cz

Methods in Molecular Biology (Clifton, N.J.)
|December 2, 2009
PubMed
Summary

P-glycoprotein (Pgp) is an ATP-binding cassette (ABC) transporter that limits drug concentration in cells. Its expression in normal tissues impacts drug absorption, distribution, and therapeutic effectiveness.

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