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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

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Related Experiment Video

Updated: Jun 18, 2026

Osteoclast Derivation from Mouse Bone Marrow
06:17

Osteoclast Derivation from Mouse Bone Marrow

Published on: November 6, 2014

The unexpected link between osteoclasts and the immune system.

Hiroshi Takayanagi1

  • 1Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Yushima 1-5-45, Bunkyo-ku, Tokyo 113-8549, Japan. taka.csi@tmd.ac.jp

Advances in Experimental Medicine and Biology
|December 2, 2009
PubMed
Summary

Osteoimmunology reveals new molecular links between osteoclasts and immune cells like B cells and dendritic cells. This discovery deepens understanding of skeletal and immune diseases, paving the way for innovative therapies.

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Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
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Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes

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Differentiation of Functional Osteoclasts from Human Peripheral Blood CD14+ Monocytes
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Area of Science:

  • Osteoimmunology
  • Molecular biology
  • Immunology
  • Skeletal biology

Background:

  • Osteoimmunology investigates the complex interplay between skeletal and immune systems.
  • Interactions between immune cells and osteoclasts are central to this field.
  • Previous research focused on macrophage-osteoclast and T-cell-osteoclast interactions, particularly in arthritis.

Purpose of the Study:

  • To explore the molecular basis of osteoclast interactions with a broader range of immune cells.
  • To identify novel molecular links between osteoclasts and immune cells beyond macrophages and T-cells.
  • To enhance understanding of diseases impacting both skeletal and immune systems.

Main Methods:

  • Literature review of recent reports on osteoclast-immune cell interactions.
  • Analysis of molecular signaling pathways shared between osteoclasts and immune cells.
  • Comparative genomics and proteomics to identify common molecules.

Main Results:

  • Recent findings highlight previously unrecognized interactions between osteoclasts and B cells.
  • Dendritic cells also demonstrate significant molecular crosstalk with osteoclasts.
  • A growing number of molecules are identified as shared by osteoclasts and various immune cells.

Conclusions:

  • The study underscores a more extensive molecular relationship between osteoclasts and immune cells than previously understood.
  • These insights are crucial for understanding the pathogenesis of diseases affecting both bone and immune functions.
  • The identified molecular links provide a foundation for developing novel therapeutic strategies for related disorders.