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Updated: Jun 18, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
A "neurosurgical crisis" of sickle cell disease
Nader S Dahdaleh1, Timothy E Lindley, Patricia A Kirby
1Department of Neurosurgery, University of Iowa College of Medicine, Iowa City, Iowa, USA.
Abstract:
The occurrence of spontaneous acute epidural hematomas is rare in patients with sickle cell disease. The authors report the case of a patient with sickle cell anemia who presented with a sickle cell crisis that was complicated by the development of multiple acute epidural and subgaleal hematomas requiring surgical evacuation. Possible underlying mechanisms are discussed. Although rare, clinicians should be aware of this phenomenon as part of a spectrum of neurological complications in these patients.
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