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Related Concept Videos

Cells and Secretions of the Pancreas01:16

Cells and Secretions of the Pancreas

12.6K
The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
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Pancreas01:19

Pancreas

2.9K
The pancreas, an essential organ in the human body, is a pinkish-gray elongated structure located posterior to the stomach. It extends laterally from the duodenum towards the spleen and is firmly bound to the posterior wall of the abdominal cavity. The organ's surface has a lumpy, lobular texture that gives it a unique appearance.
The broad head of the pancreas lies within the loop formed by the duodenum, while its slender body reaches towards the spleen. The tail of the pancreas is short...
2.9K
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.5K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.5K
Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

2.8K
The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
2.8K
Acute Pancreatitis I: Introduction01:25

Acute Pancreatitis I: Introduction

19
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
19
Acute Pancreatitis II: Pathophysiology01:21

Acute Pancreatitis II: Pathophysiology

31
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
31

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Related Experiment Video

Updated: Apr 26, 2026

Preparation of Pancreatic Acinar Cells for the Purpose of Calcium Imaging, Cell Injury Measurements, and Adenoviral Infection
10:39

Preparation of Pancreatic Acinar Cells for the Purpose of Calcium Imaging, Cell Injury Measurements, and Adenoviral Infection

Published on: July 5, 2013

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Pancreatic acinar cell metabolism and function.

P D Webster, O Black, D L Mainz

    Gastroenterology
    |December 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    This review details 11 years of research on pancreatic acinar cells, highlighting gastrointestinal hormones

    More Related Videos

    Assessing the Secretory Capacity of Pancreatic Acinar Cells
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    Assessing the Secretory Capacity of Pancreatic Acinar Cells

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    Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry
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    Related Experiment Videos

    Last Updated: Apr 26, 2026

    Preparation of Pancreatic Acinar Cells for the Purpose of Calcium Imaging, Cell Injury Measurements, and Adenoviral Infection
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    Assessing the Secretory Capacity of Pancreatic Acinar Cells
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    Published on: August 28, 2014

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    Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry
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    Isolating and Analyzing Cells of the Pancreas Mesenchyme by Flow Cytometry

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    Area of Science:

    • Gastroenterology and Hepatology
    • Cellular Biology
    • Metabolic Research

    Background:

    • Pancreatic acinar cells are crucial for digestion and nutrient processing.
    • Understanding their metabolism and function is key to pancreatic health.

    Purpose of the Study:

    • To review advancements in pancreatic acinar cell metabolism and function over the last 11 years.
    • To elucidate the role of cellular processes, hormones, and agonists in acinar cell activity.

    Main Methods:

    • Comprehensive literature review of research from the past 11 years.
    • Analysis of studies focusing on cellular structure-function relationships.
    • Examination of the impact of fasting, feeding, gastrointestinal hormones, and cholinergic agonists.

    Main Results:

    • Gastrointestinal hormones significantly mediate secretion, synthesis, and trophism in acinar cells.
    • Detailed understanding of cellular responses to feeding and fasting states.
    • Insights into the mechanisms underlying acinar cell function.

    Conclusions:

    • The reviewed data provides a foundation for investigating alcohol and drug-induced pancreatic injury.
    • This knowledge can aid in developing diagnostic tools for pancreatic diseases.
    • Understanding acinar cell function is vital for comprehending neoplastic transformation.