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Diabetic Retinopathy

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DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...

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At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category, whereas...

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Updated: Jun 18, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice

Published on: January 12, 2024

Marathon runner's retinopathy.

Leanne T Labriola¹, Thomas R Friberg, Alethea Hein

¹The Retina Service, Eye and Ear Institute, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA.

Seminars in Ophthalmology

|December 4, 2009

Summary

This summary is machine-generated.

A young marathon runner experienced sudden vision loss due to unusual retinopathy. Strenuous exercise may disrupt clotting factor balance, increasing thrombus formation risk in predisposed individuals.

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Area of Science:

Ophthalmology
Sports Medicine
Hematology

Background:

Endurance athletes may be at risk for specific vascular events.
Retinal vascular occlusions can present with sudden vision loss.

Observation:

A 25-year-old female marathon runner presented with acute monocular vision loss during training.
Fundus examination revealed subhyaloid hemorrhage, intraretinal hemorrhages, disc edema, and venous changes.

Findings:

The patient's retinal presentation mimicked Valsalva retinopathy and central retinal vein occlusion.
Systemic workup for underlying causes was negative, highlighting exercise as a potential trigger.

Implications:

Strenuous exercise can alter the balance between coagulation and fibrinolysis.
Individuals with thrombotic predispositions may face an increased risk of thrombus formation during intense physical activity.
This case underscores the importance of considering exercise-induced vascular events in athletes.