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Published on: April 10, 2018
CD9 gene variations are not associated with female infertility in humans
Sachie Nishiyama1, Taro Kishi, Takema Kato
1Division of Molecular Genetics, Institute for Comprehensive Medical Science, Toyoake, Japan.
Background/Aims:
To determine whether genetic alterations in the CD9 gene are associated with female infertility in humans.
Methods:
We sequenced the entire coding region of this gene in 86 Japanese women with unexplained infertility and further conducted a case-control study of six tagging single nucleotide polymorphisms (SNPs) in this gene using an additional 164 samples obtained from a fertile control group.
Results:
No disease-causing mutation in the CD9 gene was evident in these samples and no significant association between the tagging SNPs and the studied cohort was identified.
Conclusions:
Our findings do not support the hypothesis that genetic alterations of the CD9 gene cause female infertility in humans.
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